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	vulva cancer

Disease ID	1418
Disease	vulva cancer
Definition	Vulvar cancer is a rare type of cancer. It forms in a woman's external genitals, called the vulva. The cancer usually grows slowly over several years. First, precancerous cells grow on vulvar skin. This is called vulvar intraepithelial neoplasia (VIN), or dysplasia. Not all VIN cases turn into cancer, but it is best to treat it early. Often, vulvar cancer doesn't cause symptoms at first. However, see your doctor for testing if you notice A lump in the vulva Vulvar itching or tenderness Bleeding that is not your period Changes in the vulvar skin, such as color changes or growths that look like a wart or ulcer You are at greater risk if you've had a human papillomavirus (HPV) infection or have a history of genital warts. Your health care provider diagnoses vulvar cancer with a physical exam and a biopsy. Treatment varies, depending on your overall health and how advanced the cancer is. It might include surgery, radiation therapy, chemotherapy, or biologic therapy. Biologic therapy boosts your body's own ability to fight cancer. NIH: National Cancer Institute
Synonym	ca vulva cancer of the vulva cancer of vulva cancer vulva cancer vulvar cancer, vulva cancer, vulvar cancers, vulva cancers, vulvar malign neopl vulva nos malignant neoplasm of the vulva malignant neoplasm of vulva malignant neoplasm of vulva unspecified malignant neoplasm of vulva unspecified (disorder) malignant neoplasm of vulva, nos malignant neoplasm of vulva, unspecified malignant neoplasm of vulva, unspecified site malignant tumor of the vulva malignant tumor of vulva malignant tumor of vulva (disorder) malignant tumour of vulva malignant vulva neoplasm malignant vulva tumor malignant vulvar neoplasm malignant vulvar tumor of vulva cancer vulva cancers vulva--cancer vulval ca vulval cancer vulvar cancer vulvar cancers
DOID	DOID:1245
ICD10	ICD10CM:C51.9
UMLS	C0375071
SNOMED-CT	SNOMEDCT_US_2016_09_01:363367000
Comorbidity	UMLS \| Disease \| Sentences' Count(Total Sentences:9) C0006625 \| cachexia \| 1 C0006142 \| breast cancer \| 1 C0686619 \| lymph node metastases \| 1 C0007137 \| squamous cell cancer \| 1 C0023646 \| lichen planus \| 1 C0205944 \| epithelioid sarcoma \| 1 C0033953 \| sexual dysfunction \| 1 C0007117 \| basal cell carcinoma \| 1 C0023269 \| leiomyosarcomas \| 1
Curated Gene	(Waiting for update.)
Inferring Gene	Entrez_id \| Symbol \| Resource(Total Genes:5) 3552 \| IL1A \| CIPHER 3553 \| IL1B \| CIPHER 3557 \| IL1RN \| CIPHER 3569 \| IL6 \| CIPHER 4846 \| NOS3 \| CIPHER
Text Mined Gene	Entrez_id \| Symbol \| Score \| Resource(Total Genes:54) 196528 \| ARID2 \| 1.914 \| DISEASES 768 \| CA9 \| 2.488 \| DISEASES 960 \| CD44 \| 1.266 \| DISEASES 923 \| CD6 \| 1.929 \| DISEASES 4267 \| CD99 \| 1.834 \| DISEASES 1029 \| CDKN2A \| 4.247 \| DISEASES 1365 \| CLDN3 \| 1.129 \| DISEASES 1366 \| CLDN7 \| 2.261 \| DISEASES 10106 \| CTDSP2 \| 2.314 \| DISEASES 1499 \| CTNNB1 \| 1.019 \| DISEASES 1825 \| DSC3 \| 1.329 \| DISEASES 1942 \| EFNA1 \| 1.345 \| DISEASES 2103 \| ESRRB \| 1.806 \| DISEASES 2104 \| ESRRG \| 1.604 \| DISEASES 2130 \| EWSR1 \| 1.686 \| DISEASES 2132 \| EXT2 \| 1.036 \| DISEASES 50943 \| FOXP3 \| 1.843 \| DISEASES 6624 \| FSCN1 \| 2.17 \| DISEASES 3014 \| H2AFX \| 1.137 \| DISEASES 3106 \| HLA-B \| 1.236 \| DISEASES 3133 \| HLA-E \| 1.346 \| DISEASES 3713 \| IVL \| 1.99 \| DISEASES 3821 \| KLRC1 \| 1.14 \| DISEASES 3855 \| KRT7 \| 3.03 \| DISEASES 3963 \| LGALS7 \| 1.003 \| DISEASES 5641 \| LGMN \| 1.641 \| DISEASES 440900 \| LINC01191 \| 6.665 \| DISEASES 4148 \| MATN3 \| 1.523 \| DISEASES 554202 \| MIR31HG \| 1.23 \| DISEASES 388815 \| MIR99AHG \| 1.42 \| DISEASES 2315 \| MLANA \| 1.158 \| DISEASES 246734 \| NPCDR1 \| 1.183 \| DISEASES 5100 \| PCDH8 \| 1.806 \| DISEASES 5179 \| PENK \| 1.144 \| DISEASES 64065 \| PERP \| 1.655 \| DISEASES 5230 \| PGK1 \| 1.045 \| DISEASES 5241 \| PGR \| 1.439 \| DISEASES 5339 \| PLEC \| 2.076 \| DISEASES 84898 \| PLXDC2 \| 2.826 \| DISEASES 5728 \| PTEN \| 1.261 \| DISEASES 5743 \| PTGS2 \| 1.334 \| DISEASES 28984 \| RGCC \| 1.232 \| DISEASES 6239 \| RREB1 \| 1.896 \| DISEASES 6336 \| SCN10A \| 2.414 \| DISEASES 2810 \| SFN \| 2.595 \| DISEASES 6456 \| SH3GL2 \| 2.408 \| DISEASES 26503 \| SLC17A5 \| 1.001 \| DISEASES 9351 \| SLC9A3R2 \| 2.253 \| DISEASES 6865 \| TACR2 \| 1.547 \| DISEASES 84260 \| TCHP \| 1.155 \| DISEASES 7422 \| VEGFA \| 1.331 \| DISEASES 7465 \| WEE1 \| 2.088 \| DISEASES 340152 \| ZC3H12D \| 1.501 \| DISEASES 22834 \| ZNF652 \| 2.804 \| DISEASES
Locus	(Waiting for update.)

Disease ID	1418
Disease	vulva cancer
Integrated Phenotype	(Waiting for update.)
Text Mined Phenotype	HPO \| Name \| Sentences' Count(Total Phenotypes:5) HP:0002664 \| Neoplasia \| 3 HP:0030731 \| Carcinoma \| 1 HP:0002671 \| Basalioma \| 1 HP:0004326 \| Cachexia \| 1 HP:0003002 \| Breast carcinoma \| 1

Disease ID	1418
Disease	vulva cancer
Manually Symptom	(Waiting for update.)
Text Mined Symptom	UMLS \| Name \| Sentences' Count(Total Symptoms:1) C0686619 \| lymph node metastases \| 1

Manually Genotype(Total Text Mining Genotypes:0)
(Waiting for update.)

Text Mining Genotype(Total Genotypes:0)
(Waiting for update.)

All Snps(Total Genotypes:8)
snpId	pubmedId	geneId	geneSymbol	diseaseId	sourceId	sentence	score	Year	geneSymbol_dbSNP	CHROMOSOME	POS	REF	ALT
rs2569254	26241630	1437	CSF2	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	IL12B	5	159324241	C	T
rs2569254	26241630	3593	IL12B	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	IL12B	5	159324241	C	T
rs25882	26241630	3593	IL12B	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	CSF2	5	132075767	T	C
rs25882	26241630	1437	CSF2	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	CSF2	5	132075767	T	C
rs27438	26241630	1437	CSF2	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	NA	5	132077562	G	A
rs27438	26241630	3593	IL12B	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	NA	5	132077562	G	A
rs3181225	26241630	1437	CSF2	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	LOC105377683	5	159313615	G	A
rs3181225	26241630	3593	IL12B	umls:C0375071	BeFree	We also observed significantly increased risk of HPV-positive vulvar cancers associated with variant alleles in CSF2 (rs25882 and rs27438, 26-28% increased risk) and IL-12B (rs2569254 and rs3181225, 40-41% increased risk) genes.	0.000271442	2015	LOC105377683	5	159313615	G	A

GWASdb Annotation(Total Genotypes:0)
(Waiting for update.)

GWASdb Snp Trait(Total Genotypes:0)
(Waiting for update.)

Mapped by lexical matching(Total Items:0)
(Waiting for update.)

Mapped by homologous gene(Total Items:0)
(Waiting for update.)

Disease ID	1418
Disease	vulva cancer
Case	(Waiting for update.)

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